Terverifikasi Administratif dan Faktual oleh Dewan Pers
Athletic Bilbao 1-1 Marseille (Sabin Merino 81' ; Michy Batshuayi 40') - Bilbao lolos, agregat 2-1
Bayer Leverkusen 3-1 Sporting (Karim Bellarabi 30', 65', Hakan Calhanoglu 87' ; Joao Mario 38') - Leverkusen lolos, agregat 4-1
Krasnodar 0-3 Sparta Praha (Lukas Marecek 51', Martin Frydek 57', Kehinde Fatai 70') - Sparta lolos, agregat 4-0
Lazio 3-1 Galatasaray (Marco Parolo 59', Felipe Anderson 61', Miroslav Klose 72') - Lazio lolos, agregat 4-2
Liverpool 1-0 Augsburg (James Milner 5'-pen) - Liverpool lolos, agregat 1-0
Rapid Wina 0-4 Valencia (Rodrigo 59', Sofiane Feghouli 64', Pablo Piatti 72', Shkordra Mustafi 88') - Valencia lolos, agregat 6-0
Schalke 0-3 Shakhtar Donetsk (Marlos 26', Facundo Fereyra 63', Viktor Kovalenko 77') - Schalke lolos, agregat 3-0
Basel 2-1 Saint-Etienne (Luca Zuffi 15', 90' ; Mustapha Bayal Sall 89') - Basel lolos berkat agresivitas gol tandang, agregat 4-4
Porto 0-1 Borussia Dortmund (Iker Casillas 23'-bd) - Dortmund lolos, agregat 3-0
Manchester United 5-1 Midtjylland (Nikolay Bodurov 32'-bd, Marcus Rashford 63', 75', Ander Herrera 87'-pen, Memphis Depay 90' ; Pione Sisto 27') - Manchester United lolos, agregat 6-3