Alex Marquez untuk sementara memimpin dan Marcel Schrotter berada di belakangnya.
Thomas Luthi kemudian turut serta meramaikan perebutan posisi terdepan dan berhasil menyalip Marcel Schrotter untuk menempati posisi kedua.
Saat balapan menyisakan sembilan lap lagi, Thomas Luthi berhasil menyalip Alex Marquez meraih posisi pertama.
Baca Juga : Alasan Marc Marquez Tak Pasang Winglet Seperti Milik Ducati Lagi
Persaingan sengit terjadi antara adik Valentino Rossi yaitu Luca Marini dengan adik Marc Marquez, Alex Marquez, untuk posisi ketiga saat balapan menyisakan empat lap lagi.
Namun, secara mengejutkan Jorge Navarro berhasil menyalip Luca Marini dan Alex Marquez sehingga merebut posisi ketiga.
Di depan, Thomas Luthi berhasil mempertahankan posisi pertamanya hingga sesi balapan selesai dengan Marcel Schrotter berada di belakangnya.
Sementara itu, pembalap asal Indonesia, Dimas Ekky Pratama, finis di urutan ke-22.
Berikut hasil Moto2 Americas 2019, Senin (15/4/2019).
| Pos | Poin | Pembalap | Tim | Jarak |
| 1 | 25 | Thomas LUTHI | Dynavolt Intact GP | 39'11.508 |
| 2 | 20 | Marcel SCHROTTER | Dynavolt Intact GP | +2.532 |
| 3 | 16 | Jorge NAVARRO | Beta Tools Speed Up | +3.836 |
| 4 | 13 | Mattia PASINI | Flexbox HP 40 | +4.757 |
| 5 | 11 | Alex MARQUEZ | EG 0,0 Marc VDS | +7.741 |
| 6 | 10 | Luca MARINI | SKY Racing Team VR46 | +8.031 |
| 7 | 9 | Sam LOWES | Federal Oil Gresini Moto2 | +8.282 |
| 8 | 8 | Simone CORSI | Tasca Racing Scuderia Moto2 | +8.953 |
| 9 | 7 | Enea BASTIANINI | Italtrans Racing Team | +10.706 |
| 10 | 6 | Andrea LOCATELLI | Italtrans Racing Team | +16.868 |
| 11 | 5 | Remy GARDNER | ONEXOX TKKR SAG Team | +25.633 |
| 12 | 4 | Tetsuta NAGASHIMA | ONEXOX TKKR SAG Team | +25.948 |
| 13 | 3 | Bo BENDSNEYDER | NTS RW Racing GP | +26.997 |
| 14 | 2 | Dominique AEGERTER | MV Agusta Idealavoro Forward | +27.462 |
| 15 | 1 | Jorge MARTIN | Red Bull KTM Ajo | +27.482 |
| 16 | | Jesko RAFFIN | NTS RW Racing GP | +39.435 |
| 17 | | Khairul Idham PAWI | Petronas Sprinta Racing | +49.582 |
| 18 | | Philipp OETTL | Red Bull KTM Tech 3 | +51.247 |
| 19 | | Lukas TULOVIC | Kiefer Racing | +51.380 |
| 20 | | Somkiat CHANTRA | IDEMITSU Honda Team Asia | +53.778 |
| 21 | | Gabriele RUIU | MV Agusta Idealavoro Forward | +1'19.156 |
| 22 | | Dimas EKKY PRATAMA | IDEMITSU Honda Team Asia | +1'19.286 |
| Gagal Finis |
| | | Iker LECUONA | American Racing KTM | 5 Laps |
| | | Marco BEZZECCHI | Red Bull KTM Tech 3 | 6 Laps |
| | | Xavi CARDELUS | Sama Qatar Angel Nieto Team | 12 Laps |
| | | Brad BINDER | Red Bull KTM Ajo | 16 Laps |
| | | Fabio DI GIANNANTONIO | Beta Tools Speed Up | 0 Lap |
| | | Lorenzo BALDASSARRI | Flexbox HP 40 | 0 Lap |
| | | Xavi VIERGE | EG 0,0 Marc VDS | 0 Lap |
| | | Joe ROBERTS | American Racing KTM | 0 Lap |